Observation, Experiments, Discoveries....


Welcome to Masayuki Miura Laboratory! Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo Last update: 2018,4,24

Stuff Scientists Masayuki Miura, Ph. D., Professor Fumiaki Obata, Ph. D., Assistant Professor Soshiro Kashio, Ph. D., Assistant Professor Natsuki Shinoda, Assistant Professor Research Focus Programmed cell death functions in dynamic tissue formation or remodeling. We have revealed that in the embryonic development, or aging process, caspases are activated by physiological stresses and exert regulatory functions. We aim to reveal how cell society is constructed and maintained during development, growth, regeneration and aging process with a particular focus on understanding the regulatory mechanisms and functions of cell death. We believe that our research would stimulate and encourage students and researchers to have the breadth of vision for life science research and provide new insights into the molecular logic underlying the formation and maintenance of cell society.


Research Topics 1. Regulation and function of cell death in development, growth, regeneration and aging 2. Regulation of cell number and size of tissue via programmed cell death mechanism 3. Roles of dying cells as a signal center 4. Metabolic regulation of tissue regeneration and aging 5. Nutritional and gut microbial regulation of organismal homeostasis Review Article Kashio, S., Obata, F., and Miura, M.: How tissue damage MET metabolism: Regulation of the systemic damage response. FLY 11, 27-36, 2017 doi:10.1080/19336934.2016.1221549 Yamaguchi, Y., and Miura, M.: Programmed cell death and caspase functions during neural development. Cur. Topics Dev. Biol., 114, 159-184, 2015, doi: 10.1016/bs.ctdb.2015.07.016 Yamaguchi, Y., and Miura, M.: Programmed Cell Death in Neurodevelopment. Dev. Cell 32, 478-490, 2015, doi: 10.1016/j.devcel.2015.01.019. Igaki, T., and Miura, M.: The Drosophila TNF ortholog Eiger: Emerging physiological roles and evolution of the TNF system. Seminar Immunol. 26, 267-274, 2014, doi: 10.1016/j.smim.2014.05.003. Kashio, S., Obata, F., and Miura, M.: Interplay of cell proliferation and cell death in Drosophila tissue regeneration. Dev. Growth Diff. 56, 368-375, 2014 Lee W-J., and Miura, M.: Mechanisms of Systemic Wound Response in Drosophila. Cur. Topics Dev Biol. 108, 153-183, 2014 Miura, M.: Apoptotic and nonapoptotic caspase functions in animal development. Cold Spring Harb. Perspect. Biol. 4, doi: 10.1101/cshperspect.a008664, 2012 Miura, M.: Active participation of cell death in development and organismal homeostasis. Dev. Growth. Diff. 53, 125-136, 2011 Kuranaga, E., and Miura, M.: Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination. Trends Cell Biol. 17, 135-144, 2007
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